Endocrine Abstracts

Background and aims: Diabetes insipidus (DI) is a common complication after transsphenoidal surgery (TSS), but resolves in the majority of patients. We determined the osmolalities and timing of DI most that best predicted long-term outcome.Methods: Case series study randomly including 54 patients out of total 99 patients who underwent transsphenoidal surgery over 18 months. Follow up information was ascertained from clinic review or by telephone intervie...

Introduction and aims: Following treatment for acromegaly, both growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels are predictive of mortality. These data are derived from studies of either a single GH or the mean circadian GH, with a threshold of 2 mcg/l. However, consensus target criteria (Giustina et al. 2000) require: a nadir GH of <1 mcg/l on OGTT and IGF-I within the age/sex-adjusted normal range. We aimed to determine the degree to which norm...

Background: Prolactin levels are affected by stress, and in patients with moderate hyperprolactinaemia, a repeat test and/or a resting prolactin has been recommended, but there are very few data addressing the utility of these additional measurements.Aim: To study the value of: A) Repeat measurement and B) Resting measurement of serum prolactin in mild to moderate prolactin excess (510–7500 IU/L).Methods and subjects: Case not...